2014 Keynote Address
Dr. Stephen Lory
Dept. of Microbiology and Immunobiology
Harvard Medical School
Genome-wide detection of virulence and host recognition determinants of Pseudomonas aeruginosa
BIOGRAPHICAL SKETCH
Dr. Lory has spent his entire scientific career studying Pseudomonas aeruginosa, a bacterium widely distributed in the environment and an important human pathogen. His work as a graduate student at UCLA focused on comparison of toxins produced by this organism to other related toxic proteins. While a post-doctoral fellow at Harvard, he studied secretion of protein toxins from P. aeruginosa, a project he continued in his laboratory at the University of Washington, leading to the discovery of the type II secretion system. Here he also became interested in microbial genomics, and participated in a project that resulted in the sequencing of the first P. aeruginosa. He developed the first microarray for P. aeruginosa allowing investigators to define its transcriptome in a wide range of environments. After moving to Harvard in 2000, he was one of the early investigators in the field of cyclic nucleotide signaling. His current work exploits deep sequencing as a tool for understanding bacterial evolution and the role of small regulatory RNAs in regulation of gene expression. He is active as a manuscript and grant reviewer for the NIH and Cystic Fibrosis Foundation and has published one textbook and over 110 papers in peer-reviewed journals.
Lory Research website | Lory Laboratory website
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